Mouzon composed the song The Blue Spot for the jazz club scene, and appeared as an actor and drummer in the Tom Hanks-directed film, That Thing You Do in 1996.

He also can be seen with Michael Keaton and Katie Holmes in the film First Daughter, and as Ray in the movie The Dukes, along with Robert Davi, Chazz Palminteri and Peter Bogdanovich.

Mouzon played with Stevie Wonder,[1] Eric Clapton,[1] Jeff Beck, Carlos Santana,[1] Patrick Moraz, Betty Davis, and Chubby Checker.

Robert Plant, lead singer of Led Zeppelin, during his acceptance speech for induction into the 1995 Rock and Roll Hall of Fame, listed Alphonse Mouzon as one of the band's influences from American music.

In 2014, Mouzon was invited by producer Gerry Gallagher to record with Latin rock legends El Chicano, as well as David Paich, Brian Auger, Alex Ligertwood, Ray Parker Jr., Lenny Castro, Vikki Carr, Pete Escovedo, Peter Michael Escovedo, Jessy J, Marcos J. Reyes, Siedah Garrett, Walfredo Reyes Jr., Salvador Santana, and Spencer Davis, and is featured on drums on two tracks Make Love and The Viper, that are part of Gallagher's most recent studio album due to be released in 2019.

[1] His son, Jean-Pierre Mouzon, reported his father had died of cardiac arrest at his home in Granada Hills, Los Angeles, California, on December 25, 2016, at the age of 68.