The Alpine Institute was a Presbyterian mission school located in Overton County, Tennessee, United States.

Operating in one form or another from 1821 until 1947, the school provided badly needed educational services to children living in the remote hill country of the Upper Cumberland region.

[3] The school was re-established in 1880 at its current location at the base of Alpine Mountain, and under the leadership of future Tennessee governor A. H. Roberts continued to thrive into the following decade.

The school's faculty during this period included Dillard's son, William, and future Illinois governor John Beveridge.

[5] During the Civil War, law and order almost completely disappeared in the Upper Cumberland region, and the Alpine school was destroyed by bushwhackers.

The collegiate curriculum included courses in geometry, trigonometry, botany, chemistry, and classical studies, namely Latin and Greek.

In 1913, the Presbyterian Church USA's National Missions superintendent for Middle Tennessee toured the Upper Cumberland, and noted that the Alpine school was meeting only three months out of the year.

A subsequent survey found the region's rural areas to badly in need of basic educational facilities, and in 1917 the church's Board of Missions agreed to re-establish the Alpine Institute.