Altopascio is a comune (municipality) in the province of Lucca, in the Italian region of Tuscany, with a population of 15,572.

Already inhabited in Roman times, Altopascio gained in importance due to its Spedale (hostel, first mentioned in 1084) for the pilgrims who travelled on the Via Francigena, leading from France to Rome.

This, founded by Matilda of Canossa between 1070 and 1080, was one of the first of the military orders; it existed for four hundred years, in which it had considerable social, political and military influence, and though gaining land in various European countries retained its strong ties to the town where it was founded.

It is famous for the Battle of Altopascio in 1325 in which the Ghibelline leader Castruccio Castracani defeated the Florentines Guelphs led by Ramón de Cardona.

The Spedale declined starting from the 16th century, until Grand Duke Peter Leopold suppressed it in 1773, to favour that in Pescia.