The building's design is that of a classical temple with a well-defined base, midsection and ornamental terra cotta pediment, topped with a clay tile roof.

During the initial design process, a study was performed to evaluate the architectural and historic significance of each major area of the building.

As such, approximately 95% of the existing historical light fixtures were rewired, retrofitted with energy–efficient lamps, refinished, and rehung in their original locations.

One thousand square feet of marble flooring originally from Pennsylvania Hall (the previous home of Pitt's medical school since torn down) was utilized in vestibules, corridors, elevator lobbies and cabs.

Modern emergency fire and electrical systems were added as well as conduits for wiring installations for data and power for 380 of the building's classroom seats.

The seventh-floor auditorium lobby/reception area houses the collection of oil paintings, "365 Views of the Cathedral of Learning", completed in 1997–1999 by renowned Spanish artist Felix de la Concha.