She is the first woman to call a FIFA Men's World Cup game on English-language U.S. television, serving as the analyst alongside Derek Rae for Iran's 1–0 win against Morocco on June 15, 2018.

[7] Wagner began playing with the United States women's national soccer team in 1998, while still a freshman at Santa Clara University.

[15] In 2009, Wagner began playing midfielder for the Los Angeles Sol of Women's Professional Soccer (WPS).

In 2007, Wagner was selected by head coach Greg Ryan for the 2007 FIFA Women's World Cup in China and competed in the third-place play-off match against Norway.

[18] Despite undergoing a double hernia operation in early 2008, Wagner was selected to play at the 2008 Summer Olympics and made one appearance as a substitute in a group-stage match against New Zealand.

She worked as a Fox Sports match analyst during the 2015 FIFA Women's World Cup,[21] and became the first woman to call a FIFA Men's World Cup game on U.S. television[2][21] by serving as the analyst alongside Derek Rae for Iran's 1–0 win against Morocco on June 15, 2018.

[21][24] CBS Sports named Wagner as the host of its 2022 National Women's Soccer League (NWSL) coverage series "Groundwork".

[26] She is also a founding owner, co-chair, and alternate league board representative for the NWSL expansion club awarded to the San Francisco Bay Area in 2023.

[3][4] Wagner had helped organize a group of former USWNT players to lobby the NWSL for a team, and was credited with convincing Sixth Street Partners CEO Alan Waxman to have the fund lead investment in the bid.