[3][4][5] Padamsee was born in Bombay in 1928 into a traditional Ismaili Khoja Muslim family hailing from the Kutch region of Gujarat.

[6] The ancestors of the Padamsee family originally belonged to the Charan community of Kutch who later converted to Islam.

Her eldest son was Sultan Padamsee, also known as Bobby, a theatre actor who was reputedly gay and died by suicide at the age of twenty-three.

Alyque and his brothers (but not his sisters) were the first in the family to attend school and learn English there; the parents later picked up a smattering of the language from their sons.

[9] Raised in an extremely traditional environment, in a devout Muslim family, Padamsee described himself as an agnostic who disclaimed all religion by the age of 18.

Pearl had been previously married; her first husband had been a Hindu, and she had two children by that marriage, a daughter named Rohini (1951–1961) and a son, Ranjit Chowdhry (1955–2020).

For 14 years, Padamsee was the Chief Executive who built Lintas India to be one of the top agencies in the country.

[citation needed] Padamsee created Lalitaji for Surf, Cherry Charlie for Cherry Blossom Shoe Polish, the MRF Muscle Man, the Liril girl in the waterfall, the Kamasutra couple, Hamara Bajaj, the TV detective Karamchand, the Fair & Handsome brand, etc.

[citation needed] Padamsee is also known for his English language theatre productions in India like Evita, Jesus Christ Superstar, Tuglaq, and his latest, Broken Images, which was invited to the Kennedy Center in Washington, DC in 2011.

Earlier he worked as Communications Advisor to Chandrababu Naidu, the former Chief Minister of Andhra Pradesh State.