[9] Andrés Usme was signed as manager for the 2019 season,[10] in which América qualified for the knockout stages without much trouble, and reached the final series for the first time after defeating Atlético Nacional in the quarter-finals and Millonarios in the semi-finals.

Along with team captain Catalina Usme, goalkeeper Natalia Giraldo, midfielder Carolina Pineda, and striker Linda Caicedo were among the most outstanding players América featured in this campaign.

[13] In the 2020 Colombian Women's Football League, América advanced to the knockout stages after topping their group with 15 out of 18 points, only losing one match against crosstown rivals Deportivo Cali.

After defeating Atlético Nacional and Millonarios in successive order just like in the previous season, they faced Santa Fe in the finals, losing both matches to end up as league runners-up.

[15] They once again took part in the Copa Libertadores Femenina in which they won all their group stage matches and reached the semi-finals where they were beaten by Palmeiras and later claimed another third place finish in the competition with a 5–0 win over Deportivo Cali.