AmSouth was in the financial services industry and at its peak employed over twelve thousand people.

AmSouth's size more than doubled in 2000 when it absorbed Nashville, Tennessee-based First American National Bank.

As part of the deal, AmSouth also acquired Deposit Guaranty Bank (which was operating as a subsidiary of First American).

On May 25, 2006, AmSouth announced it would merge with Regions Financial Corporation, another Birmingham-based bank, in a $10 billion deal.

[2] AmSouth branches in Alabama, Florida, or Columbus, GA, either closed or converted to Regions on July 13, 2007.