Amad made his senior international debut for the Ivory Coast in March 2021, in a 2021 Africa Cup of Nations qualification game.

[11] He scored six goals and made six assists in 25 league games, helping Atalanta win the Campionato Primavera 1 in 2019–20 for a second successive season.

[12] Amad made his Serie A debut on 27 October 2019, coming on as a 79th-minute substitute against Udinese, and scored his first goal four minutes later in a 7–1 home win.

[16] On 5 October 2020, Manchester United agreed to sign Amad in January 2021, pending the agreement of personal terms, passing a medical and the issue of a work permit.

[23] On 18 February, Amad made his first-team debut for United as a substitute for Mason Greenwood in a 4–0 away win over Real Sociedad in the first leg of the Europa League round of 32 tie.

[26] Amad played his first game of the 2021–22 season on 8 December 2021, starting the UEFA Champions League group stage match against Young Boys.

[37] Following the dismissal of Erik ten Hag, Amad saw regular playing opportunities, first under interim manager Ruud van Nistelrooy, then head coach Ruben Amorim.

[38] On 7 November, in Van Nistelrooy's penultimate game in charge, Amad scored his first brace for the club in a 2–0 win against PAOK in the UEFA Europa League.

[40] On 15 December, he started as an attacking midfielder away to local rivals and reigning champions Manchester City, where he notably won a late penalty which Bruno Fernandes converted to equalise, then scored the winning goal in the final minutes their in 2–1 victory.

[43] On 12 January, Amad made his 50th appearance for United, coming on as a substitute in their FA Cup third round match against Arsenal, which ended in a 1–1 draw after extra time.

[44] On 16 January, Amad scored his first senior hat-trick in 12 minutes against Southampton in a 3–1 victory, helping Manchester United to come from behind in the second-half.

[48] On 5 June 2021, Amad scored his first international goal in a friendly against Burkina Faso, through a 97th-minute free kick, to help his team win 2–1 at home.

[53] A winger who is also capable of playing as a mezzala, Amad is a quick and dynamic player with a high technical ability and a good vision of the game.

[8] He was accused of falsifying documents in order to fake a relationship with Hamed Mamadou Traoré, an Ivorian citizen resident in Italy, and request a family reunification.