Residence, which was very modern and comfortable according to the ideas of the time, is, like the house not far from it, of the one whom Frederick III had it built for himself and his wife Princess Johanna Franziska of Hohenzollern-Sigmaringen, preserved largely true to the original.

[1] Following her parents' request, on 29 November 1781 in Strasbourg, on the occasion of the marriage of Frederick III with Johanna Franziska, was announced the betrothal of Amalie Zephyrine with the Erbprinz Anton Aloys Meinrad Franz, heir of the Principality of Hohenzollern-Sigmaringen and brother of her sister-in-law;[3] the wedding took place on the Piaristenkloster Kirn on 13 August 1782,[4] with the formal reception being celebrated in the Schloss Dhaun, five kilometers away.

[11] Shortly after, Amalie Zephyrine also left Kirn and returned to her native Paris, where her brother Frederick III had commissioned the built of an aristocratic palace as a residence for the Salm-Kyrburg family to the architect Pierre Rousseau from 1782 to 1787; the residence, named the Hôtel de Salm (located on the Rue de Lille and next the Quai d'Orsay) soon became in the gathering place for the aristocratic upper class of pre-revolutionary France, with Amalie Zephyrine as hostess –eventually, the Hôtel was seized by the Revolutionary government and is today the Palais de la Légion d'Honneur and being remodeled for that purpose by Antoine-François Peyre in 1804–.

Five years later, on 23 August 1790, her sister-in-law Johanna Franziska, Princess consort of Salm-Kyrburg, also died; from her marriage with Frederick III, she had four children, one daughter and three sons, but only the youngest of the sons, Frederik Ernst Otto Philip Anton Furnibert (born 14 December 1789), survive infancy and became in the Erbprinz of Salm-Kyrburg as heir of his father.

However, in March 1794 both men were imprisoned in the Carmes Prison during the Reign of Terror after being accused of being "still attached to the Ancien Régime" and guillotined on 23 July.

Since the beginning, the protection that the princess gave to the girl gave rise to rumours; recent research suggests that in fact, Helene was Amalie Zephyrine's illegitimate daughter, born from her extramarital relationship with the French Colonel Charles de Voumard (who later called himself Karl Heinrich Voumard von Wehrburg; born 1761 – died 1841), who had been appointed by the princess in 1797 as tutor of her eight-year-old orphaned nephew Prince Frederick IV of Salm-Kyrburg.

[12] From the Second Congress of Rastatt in 1799 to the Rhine Confederation Act in 1806, Amalie Zephyrine used her relationships with the Napoleonic court to work in favor of her son Karl for the preservation of the Principality of Hohenzollern-Sigmaringen and its full sovereignty.

At the end, she was able to avert the imminent Mediatisation of both the Houses of Hohenzollern-Sigmaringen and Hohenzollern-Hechingen in favor of the Kingdom of Württemberg or the Grand Duchy of Baden; for this, she is considered as the "savior" of the Hohenzollerns.

[2] At the same time, Amalie Zephyrine campaigned for the newly created Principality of Salm and represented the interest of its designated princes, her underage nephew Frederick IV of Salm-Kyrburg (of whom she was guardian and regent) and Konstantin of Salm-Salm.