Formerly a model,[1] Byram started her career on television in 1999 presenting the TV3 morning show Ireland AM with Mark Cagney, during which time she met her then-boyfriend, comedian Patrick Kielty.

Byram hosted the Miss World pageant in 2003 and briefly appeared in David Hewlett's 2006 film A Dog's Breakfast.

Byram served as the host for the Fox reality television special Seriously, Dude, I'm Gay, which was set to air on June 7, 2004.

Speaking on the special's cancellation, Byram commented: "Of course it is always disappointing when things don’t air, but TV and the FCC is very sensitive right now, and I roll with the decisions made by the Fox network, as they have been and continue to be very supportive to me.

"[2] In 2007 she co-hosted, along with Dennis Miller, the Game Show Network programme Grand Slam, a US version of the British quiz format.

She hosted the Meteor Music Awards at the RDS, Dublin on 17 March 2009 and appeared on The Cafe on 30 January to publicise her selection.

As the celebrity on the losing team, she had to endure the forfeit trick at the end of the episode, laying on a bed of nails while a motorcycle drove over her and Chris Korn.

In November 2016, it was reported and later confirmed that Byram would host the Irish version of Dancing with the Stars alongside Nicky Byrne.