She made her big screen debut playing Miss Minneapolis in 1999 comedy film Drop Dead Gorgeous, and later had a supporting role in Final Destination.
In the early 2000s, Detmer had starring roles in comedy films, including Boys and Girls (2000), Saving Silverman (2001), The Majestic (2001), and Kiss the Bride (2002).
In 2000, she appeared as Terry Chaney in the supernatural horror film Final Destination and in the romantic comedy Boys and Girls alongside Freddie Prinze Jr., Jason Biggs and Claire Forlani.
[4] The following year, Detmer had major roles in comedy film Saving Silverman with Jason Biggs and romantic comedy-drama The Majestic, directed and produced by Frank Darabont, starring opposite Jim Carrey.
In 2017, Detmer was cast in the unaired television pilot for Red Blooded, for a series meant to star Reba McEntire,[9] which American Broadcasting Company passed on.