She has also starred in episodes of other television series including, Southland, CSI: Cyber, Game Shakers, The Big Bang Theory, Workaholics, Animal Kingdom, NCIS, Modern Family, Grey's Anatomy, and Young Sheldon.
In 2018, Payton joined the second season of the NBC sitcom Trial & Error, playing Nina Rudolph, a podcast host who moves to the series' fictional town of East Peck, South Carolina from New York to follow the trial of Lavinia Peck Foster (played by Kristin Chenoweth), and ends up in a love triangle with the characters, Josh and Carol.
[5] In 2020, Payton joined the Sky Comedy British police procedural comedy-drama Code 404, playing American scientist Dr. Alison Parfit, who leads an artificial intelligence project to revive a killed Detective Inspector using AI.
[7] In 2021, Payton had a recurring role in the sitcom United States of Al playing Holly, the girlfriend of former Marine combat veteran, Riley Dugan.
In January 2022, it was announced that Payton would star in the upcoming NBC drama Unbroken as Ella, a winemaker at a Californian ranch who tries to keep her family together since her mother's passing.