She graduated from SUNY-Purchase, then earned a master's degree in American studies with a concentration in Hip hop from Columbia University.

[14] Seales hosts, alongside judges Kenan Thompson, Chrissy Teigen, and Jeff Foxworthy.

[15] Throughout 2019, Seales served as a frequent guest host for the syndicated daytime talk show The Real.

[17] She departed the series after six months of co-hosting, citing her dissatisfaction with the inability to openly speak on recent social issues as a reason.

[21] In February 2022, Seales was cast in the three-part documentary series Everything's Gonna Be All White, airing on Showtime.

[28] On April 18, 2022, Seales began co-hosting a new weekly radio show, Amanda Seales’ Smart Funny & Black Radio on SiriusXM, alongside Taj Rani and JeremiahLikeTheBible, featuring topics such as games, celebrity interviews and African-American culture.

It is a volume of essays, axioms, original illustrations, and photos from her trademark "self-help from the hip” style of commentary.

[30] In 2019, Seales was involved in a controversy where many people mistakenly reported that she had accused former NFL player and neurosurgeon resident Myron Rolle of sexually harassing several women.

[34] In February 2020, Seales drew controversy while on The Real when defending Jussie Smollett after he was arrested for faking a hate crime.

While describing the accusations as alleged, she went on to defend the actor saying, "Even if it was a hoax for the sake of bringing attention to this, then I’m like, that’s low-key noble".