She is known for her recurring role as Penelope Shafai on The CW's teen drama Gossip Girl (2008–2012), for her role as Kimberly Andrews on the ABC soap opera One Life to Live (2009–2011) and as Brook Lynn Quartermaine on the ABC soap opera General Hospital.

Setton was born in New York City and grew up in Great Neck, where she was vice president of her high school's theater club.

Setton completed a comprehensive, two-year Meisner technique program at The Actor's Workshop of Ithaca under the instruction of Eliza VanCort.

The website Daytime Confidential reported on February 21, 2010, that Setton had taped her last episode as Kim on One Life to Live despite being offered a contract and a pay increase.

The role reunited her with General Hospital executive producer Frank Valentini, who was also her boss at One Life to Live.