A man and a woman who love each other have to confront the world in order to defend their feelings.

Colonel Miguel Santana's daughter Barbara helps him escape from jail and takes him to the arid desert to hide.

They are chased by Miguel Santana who makes them go through many dangerous adventures in search for freedom.

Desert Lovers is a passionate and adventurous love story that takes place between the 1950s and 1960s.

It stars Andrés Bustamante as a young, modest doctor, and Bárbara Santana as a woman who was born in a time when very conservative ideas ruled society.