The Dusters, quarterbacked by Julian Reese, came from 21 points down at the start of the fourth quarter to win Round 1 over the Oklahoma City Yard Dawgz.

Quarterback Steve Panella was injured early in the season, forcing numerous backups to take the job.

Carthel left to take the head coaching job at West Texas A&M two games into the Dusters first AF2 season.

For 2005, Steve Perdue took over the head coaching job and lead the team playoffs and a first round victory over the Oklahoma City Yard Dawgs.

After a win against the Lubbock Renegades the Dusters struggled for the remainder of the year but were still able end the Quincy Carter-led Bossier-Shreveport Battle Wings' perfect season with a 51–49 upset.

On July 5, 2008, Dusters running back Donte Newsome was shot to death outside of a nightclub in Huntington, West Virginia, home of his alma mater Marshall University.

[4] In 2008, under the leadership of head coach Chris MacKeown and quarterback Julian Reese, the Amarillo Dusters went 10–9 and played for the AF2 National Conference ArenaCup Finals.

Following the Dusters most successful season in their AF2 history, MacKeown moved up to the Arena Football League as the offensive coordinator for John Elway's Colorado Crush.

On October 9, 2009, it was announced that, because of a 65–35 percent margin in the fan vote, the Dusters would be moving to the Indoor Football League for the 2010 season.

Owner Randy Sanders applied for his team's spot in the Indoor Football League (IFL)[6] and they were accepted as an expansion franchise.

The Venom qualified for the playoffs in each of the next five seasons, including making it to the 2016 championship game where they lost to the Wichita Force 48–45.

Amarillo and West Texas officially left the CIF and turned their Lone Star Series from the previous season into the Arena Football Association (AFA) in November 2021.

[15] This in part due to the trademark previously held by the original Arena Football League has been allowed to elapse.