The airline operated commercial passenger services out of its hubs at Carrasco International Airport and Laguna del Sauce International Airport to most major South American destinations, as well as several secondary destinations in the Southern Cone.

In April 2015, the Bolivian airline Línea Aérea Amaszonas reached an agreement with the Uruguayan company BQB Lineas Aereas, thus obtaining the transfer of its permits to enter the aforementioned airline's airspace and changing its name to Amaszonas Uruguay in exchange for maintaining 30 employees of this airline.

The airline announced the suspension of operations on November 19, 2020.

[1] The airline officially ceased all operations on January 21, 2021.

[2][3] Amaszonas Uruguay flew to the following destinations:[4] As of January 2021, Amaszonas Uruguay's fleet consisted of the following aircraft:[5] Amaszonas Uruguay formerly operated the following aircraft:[5] Media related to Amaszonas Uruguay at Wikimedia Commons