Amatitán is the seat of a municipality in the Mexican state of Jalisco, and is home to one of the world's largest tequila distilleries.

It is the location of “La Hacienda de San José del Refugio”, a distillery which makes “Tequila Herradura” and “Tequila Jimador” and is the main source of employment for the residents of the town and surrounding communities.

The Town of Amatitán is the administrative center for the "Municipio de Amatitán" which also includes the surrounding communities of Santiaguito, Villa de Cuerámbaro, Chome, La Mata, La Conchilla, El Amarrilo, Agua Fría, Santa Rosa and several other smaller settlements.

The economy of the municipality of Amatitán, like that of the surrounding areas, relies heavily in the production of tequila beverage.

There is usually one rainy period during the year that lasts from June through September, when most of the residents grow their other dominant crop, corn, which requires significantly more water.