[2] The origins of the Amazon Federal Territory date back to the Río Negro canton of the Guayana Province, which covered an area similar to the current state and part of the Colombian departments of Vichada and Guainía, and with capital in San Fernando de Atabapo.

When the Federal Revolution came to power under the command of Juan Crisóstomo Falcón in 1864, the name was changed to Amazonas Federal Territory made up of the departments of San Fernando de Atabapo, San Carlos and Maroa.

[3] The political-administrative changes promoted by Antonio Guzmán Blanco, meant that from 1881 to 1893 said territory was divided into two; the Amazonas Federal Territory with capital in Maroa, and the Alto Orinoco Federal Territory [es] retaining San Fernando de Atabapo as capital.

In 1893, the name "Amazon Federal Territory" was resumed with capital again in San Fernando de Atabapo until 1928, when it was decided to move the capital to Puerto Ayacucho to make it more accessible to the rest of Venezuela.

On 23 July 1992, the Congress of the Republic, currently the National Assembly, elevated the category of Federal Territory to state.