She made her film debut in Ferzan Özpetek's Saturn in Opposition (2007) for which she won the David di Donatello for Best Supporting Actress as well as the Nastro d'Argento for Best Supporting Actress, the Ciak d'oro and the Globo d'oro.

She continued working as an actress in films like Black and White (2008), The Immature (2011), Viva l'Italia (2013), Do You Remember Me?

She also hosted the shows Super, Non dimenticate lo spazzolino da denti and Cominciamo bene estate during the subsequent years, as well as Stasera niente MTC in MTV Italy.

[5] The following year she recorded a Spanish version, Te pertenezco, which was a moderated hit reaching No.

Angiolini won the Nastro d'Argento, the David di Donatello for Best Supporting Actress and the Ciak d'oro alla rivelazione dell'anno for her role in Saturno contro (2007) directed by Ferzan Özpetek.