Ambrose Rayappan (25 February 1901 – 24 November 1999) was the tenth and the first indigenous Archbishop of the Archdiocese of Pondicherry and Cuddalore.

He was ordained as a priest for the Diocese of Coimbatore on 16 December 1923.

[2] On 8 January 1953 he was appointed auxiliary bishop of Pondicherry and Cuddalore, and was consecrated on 25 March 1953 by Auguste-Siméon Colas.

He was appointed as coadjutor of the same archdiocese on 7 August 1953.

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