In 2002 she sang Dido in Purcell's opera under Stephen Stubb, and went on to make her debut in the role of Pamina with the Orchestre National d'Ile de France with Alain Altinoglu conducting.

René Jacobs noticed her and invited her to take part in a new production of Sartorio's Giulio Cesare at the Innsbruck Ancient Music Festival, conducted by Attilio Cremonesi.

Amel Brahim-Djelloul later took part in William Christie's Jardin des Voix with whom she appeared on the most renowned stages in the world including the Cité de la Musique in Paris, the Barbican in London, the Grand Théâtre of Geneva, the Grand Auditorium in Madrid, and the Lincoln Center in New York.

She made her debut at the Festival International d'Art Lyrique at Aix-en-Provence in July 2005 in the role of Servilia in a new production of La clemenza di Tito.

Particularly admired for the quality of her voice and its opulent, sunlit timbre, Amel Brahim-Djelloul appears regularly in recitals with Claude Lavoix, Anne le Bozec and Anne-Céline Barrère, for instance in April 2006 at Lille Opera and in June 2006 at the Saint-Denis Festival.