The show mainly covers politics, and under former hosts, was intended as a broad-audience rundown of the day's news events, including entertainment topics.

It airs on its affiliates either live or on tape delay, along with distribution through the iHeartRadio app and podcast providers.

Since 2020, Kelly has been based at KPRC in Houston, a station owned by Premiere Networks parent company iHeartMedia, Inc.

[7] In a December 2021 interview with Tucker Carlson, he criticized President Biden’s Vice Chairman of the Joint Chiefs of Staff Christopher W. Grady further stating that "We don't need a military that's woman-friendly, that's gay-friendly" we need men "who want to sit on a throne of Chinese skulls.

"[8][9][10] Senator James Lankford (R-OK), who negotiated a bipartisan border bill on behalf of the Republican caucus over 4 months from November 2023 to February 2024 said on the floor of the Senate in February that a right-wing media personality had told him “flat out—before they knew any of the contents of the bill, any of the content, nothing was out at that point—that told me flat out, ‘If you try to move a bill that solves the border crisis during this presidential year, I will do whatever I can to destroy you, because I do not want you to solve this during the presidential election'" Lankford added, “[They] have been faithful to their promise and have done everything they can to destroy me in the past several weeks.” Jesse Kelly then asserted on X that he was the person who had threatened Lankford, and called Lankford a “eunuch.”[11][12] In April 2024, Premiere renewed The Jesse Kelly Show into 2027.