ACS Center is connected via two indoor pedestrian bridges to the ground abyss of the AmericasMart building 3, across Williams Street to the east.

In addition to housing the headquarters of the American Cancer Society, the Center also provides office space for AT&T, InComm, Internap, Turner Broadcasting System, and US South Communications.

The lower levels (Ground and Mezzanine) consist of meeting and conference rooms, a few business offices, and a 450-seat, two-level theater.

The Bridge level (with 22-foot (6.7 m) high ceiling), above Mezzanine, houses Park View Café, a cafeteria-style breakfast and lunch restaurant, and Internap.

The Bridge level was originally named Expo, and consisted mostly of convention floor space, requiring a very high ceiling.