The church is located in central Paris between the Champs-Elysées and the River Seine at 23 avenue George V in the 8th arrondissement.

Consecration of the church took place on Thanksgiving Day, 25 November 1886, which coincided with the dedication of the Statue of Liberty in New York.

[5] The cathedral appears in the painting Après l'Office à l'Église de la Sainte-Trinité, Noël 1890 ("After the Service at Holy Trinity Church, Christmas 1890") by Jean Béraud.

[7] The congregation of the American Cathedral is composed of around four hundred permanent parishioners supplemented by many students, tourists, and business travelers.

The building hosts a bilingual Montessori school, recovery groups such as AA, a weekly free concert series on Sundays sponsored by Les Arts George V, and many more community-based services.