The American Express Building-Carroll, also known as the Carroll Express Building is a historic structure located in Carroll, Iowa, United States.

Like the Chicago & Northwestern Passenger Depot across the street, the express building is an example of a replacement station built during the Golden Age of Steam Railroading.

The Chicago and North Western Railway (CNW) had built two branch lines from Carroll in 1877 and 1880, which increased business and necessitated the building of the original express building between 1883 and 1888.

Chicago architect Charles Sumner Frost designed this building, and the depot.

The building was listed on the National Register of Historic Places in 1990.