The second season of American Gods, based on Neil Gaiman's novel of the same name, was broadcast on Starz between March 10 and April 28, 2019, and consisted of eight episodes.

[23] On January 12, 2018, Starz President and CEO Chris Albrecht clarified the ongoing struggle with mounting a second season, including Gillian Anderson's and Kristin Chenoweth's involvement, Fuller and Green's continued involvement – stressing that they were never fired, nor did they quit – given their schedules, and showrunner and budget concerns, while stressing the difficulty of adaptation and the network and Fremantle Media's continued commitment to the series.

[24] On February 2, 2018, Jesse Alexander, writer for Fuller's Hannibal and Star Trek: Discovery, was announced as co-showrunner for the second season alongside Gaiman.

Cast members were unhappy with the new scripts and they were often rewritten on set, including Ian McShane improvising dialogue.

On Rotten Tomatoes, it has a 61% rating with an average score of 6.05 out of 10 based on 106 reviews with the consensus stating: "American Gods retains its bombastic style but loses its divine inspiration in a derivative second season that, after a change in show-runners and even some crucial cast members, feels like a false idol.