The American Mideast Conference (AMC) was an affiliate of the National Association of Intercollegiate Athletics that included eight member institutions in Ohio, Pennsylvania, New York, and Massachusetts.

The name change was the first step in a multi-phase expansion that extended the conference into states beyond Ohio before the league was eventually disbanded in 2012.

In its final five years the conference experienced a number of changes, with numerous members moving to the National Collegiate Athletic Association (NCAA).

Also in June 2011 former AMC members Cedarville, Notre Dame College, Urbana, and Ursuline College announced the creation of a new NCAA DII conference that hoped to develop and expand for an anticipated lifting of the moratorium on new NCAA DII conferences in 2013.

With the addition of Fisher College from the collapsed Sunrise Athletic Conference, there were reports that the AMC would operate as an eight team conference in 2011–12 with the eight teams being Carlow, Daemen, Fisher, Houghton, Point Park, Roberts Wesleyan, Wilberforce, and Walsh.