APSA's headquarters are at 1527 New Hampshire Avenue NW in Washington, D.C., in a historic building that was owned by Admiral George Remy, labor leader Samuel Gompers, the American War Mothers, and Harry Garfield, son of President James A. Garfield and president of the association from 1921 to 1922.

APSA's mission is to "support excellence in scholarship and teaching and informed discourse about politics, policy and civic participation.

"[4] APSA conducts several annual conferences, which provide an environment for scholars and other professionals to network and present their work, along with other pertinent and useful resources.

The annual residential workshops are led by a joint U.S. and African organizing team and aimed at mid-and junior-level scholars residing in Africa.

They will enhance the capacities of political scientists and their resources in East and West Africa while also providing a forum for supporting their ongoing research.

[6] The Centennial Center, its facilities, and research support programs continue to be made possible in part through the donations of APSA members.

Since 1953, it has brought select political scientists, journalists, federal employees, health specialists, and other professionals to Capitol Hill to experience Congress at work through fellowship placements on congressional staffs.

The nine-month program begins each November with an intensive one-month introduction to Congress taught by leading experts in the field.

The APSA publications program attempts to fill the diverse needs of political scientists in academic settings as well as practitioners working outside of academia, and students at various stages of their education.