APUS maintains corporate and academic offices in Charles Town, West Virginia.

About 56% of APUS students reported that they served in the military on active duty at initial enrollment.

Initially, the main goal of the university was to meet the unique educational needs of military personnel needing courses in specialized areas, such as counterterrorism and military intelligence, that were not included in typical university course offerings.

[9] In 2016, the university was listed as tied for 58th place in U.S. News & World Report ranking of online bachelor's degree Programs.

In September 2016, Vernon Smith was named senior vice president and provost, succeeding Powell.

[12] In September 2019, Angela Selden was named CEO of APEI, succeeding Boston as head of the parent company.

[24][25] The Veterans Education Project reported that American Public University System would be the largest for-profit college chain negatively affected by the modified rule.

[28][17] The investigation ended in a settlement in which APUS paid $270,000 to the state to provide relief to eligible AMU students, and has agreed to change its disclosures to prospective students,[17] and the designation was removed.

[39] American Military University participated in the Servicemembers Opportunity Colleges program before it was disbanded in 2019, with eligible bachelor's degrees in Homeland Security, Intelligence Studies, Emergency and Disaster Management (Coast Guard only), Criminal Justice, Management, and Business Administration.

[41] According to the College Scorecard, American Public University has an 8-year graduation rate of 22 percent, with a salary after completing ranging from $15,650 (AA in Human Development) to $76,460 (Bachelors in Fire Protection).