The vision for AUPP originated with Dr. Chea Vandeth along with Dr. Kem Reat Viseth, the former Director of the School of Graduate Studies of the National School of Management, and Dr. Kenneth Dunn, a Fulbright Scholar to Cambodia, who together conceptualized a new university that would embody international best practices and offer academic programs of the highest quality.

At the same time, an International Advisory Board was created, including experienced educators, administrators, and business leaders from the U.S. and Cambodia.

This agreement also allows AUPP students to study abroad at UA or at FHSU in the United States for one or two semesters, depending on their choice of major.

[8] AUPP offers undergraduate minors in the following disciplines: The American University of Phnom Penh offers the following graduate degrees:[9] The American University of Phnom Penh (AUPP) emphasizes that a student's college experience should extend beyond academics to include personal growth, community engagement, and overall development.

AUPP strives to foster an inclusive and supportive environment where students can thrive, encouraging them to engage with their peers and participate in a wide range of activities designed to enhance their college experience.