American Vampire continued under the newly created DC Black Label imprint after Vertigo was closed in January 2020.

The first of this new species is a notorious outlaw named Skinner Sweet, who wakes from death, after being infected, to find he has become a new kind of vampire, something stronger and faster than what came before, impervious to sunlight, with a new set of strengths and weaknesses.

The first, "Survival of the Fittest", illustrated by Sean Murphy focuses on the cases files of the V.M.S., the vampire hunting organization of the series.

A one shot co-written by Snyder and Albuquerque (who also illustrates the 64-page issue), entitled "Long Road to Hell" which features vampire hunter Travis Kidd, was released in June 2013.

Here, the author claims that his work – which has been long considered a fictional western/terror story – is actually based on true events which he has either witnessed or has collected reliable information on.