Amesti is a census-designated place (CDP) in Santa Cruz County, California, United States.

The population density was 1,138.2 inhabitants per square mile (439.5/km2).

There were 1,015 housing units at an average density of 332.2 per square mile (128.3/km2), of which 61.5% were owner-occupied and 38.5% were occupied by renters.

The population density was 833.0 inhabitants per square mile (321.6/km2).

There were 781 housing units at an average density of 267.1 per square mile (103.1/km2).

The racial makeup of the CDP in 2010 was 30.6% non-Hispanic White, 0.3% non-Hispanic African American, 0.5% Native American, 2.2% Asian, and 1.1% from two or more races.

[22] Of the 760 households 38.6% had children under the age of 18 living with them, 61.2% were married couples living together, 11.1% had a female householder with no husband present, and 22.5% were non-families.

In the California State Legislature, Amesti is in the 17th Senate District, represented by Democrat John Laird, and in the 30th Assembly District, represented by Democrat Dawn Addis.