He is an assistant coach for the Boston Celtics team of the National Basketball Association (NBA).

He played college basketball for the Duke Blue Devils, where he served as a captain for three seasons, including for the 2014–15 NCAA championship team.

[1] Jefferson was born and raised in Philadelphia and attended Friends' Central School[2] where he was coached by Jason Polykoff.

With his solid play, Jefferson was selected for the 2012 McDonald's All-American Game,[3] where he scored eight points and grabbed three rebounds.

He was a USA Today second-team All-USA as a senior in 2012 after averaging 19.9 points, 10.2 rebounds and 2.7 steals per game.

He helped lead Duke to a 124–26 record in games in which he played, the third-most victories in program history.

He was a member of the All-ACC Academic Team and appeared in 32 games with seven starts, averaging 4.0 points and 2.9 rebounds.

He was named to the ACC All-Tournament second team after averaging 7.7 points and 8.0 rebounds to help lead Duke to the championship game.

He played a career-high-tying 35 minutes in a home win over Indiana (12/2), finishing with 11 rebounds, a career-best eight assists and three blocks.

A Hall of Fame Tip-Off All-Tournament Team member after averaging 16.5 points and 15.0 rebounds in two games in Connecticut as Duke captured the tournament trophy.

He was named ACC Player of the Week once (12/12) and was a member of the preseason watch list for the Karl Malone Award.

After graduating with his Masters from Duke, Jefferson signed on with the Minnesota Timberwolves for 2017 summer league action, which ran from July 7 to 17 in Las Vegas, Nevada.

[9] He joined the Iowa Wolves, Minnesota's development team, in the NBA G League as an affiliate player.

[10] Subsequent to the 2017 All-NBA G League Showcase, on January 15, 2018, the Minnesota Timberwolves signed Amile Jefferson to a two-way contract.

[13] As a member of the Iowa Wolves, Jefferson averaged 35 minutes per game with 18 points and 13 rebounds (NBA G League leader).

[14] His strong performance in the first half of the season generated considerable buzz, with a highlight being his leadership during the team's first matchup of the 2018 NBA G League showcase.

[21] Jefferson made his NBA debut on December 31, 2018, against the Charlotte Hornets, playing four minutes with two points and one rebound.

[27] On December 29, 2020, Jefferson signed with Galatasaray of the Turkish Basketball Super League (BSL).

[28] On July 21, 2021, Jefferson was named Director of Player Development for the Duke Blue Devils.