His father was the Sufi scholar Saif ud-Dīn Hamza (سیف الدین حمزہ), a sayyid descendant of Muhammad.

By this time his reputation as a scholar and religious figure had spread through Chagatai Khanate and the title Amir-i-Kulal, had become his common name.

The builders of the madrasa were members of the Kulal tribe and copied the Kalyan mosque (Po-i-Kalyan) style, making upgrades in the design and technology.

[6] The tribe quickly established a small industrial base at the central market of Vabkent and built mills in the surrounding areas, which continued to operate well into the sixteenth century.

Utilizing wind and water resources for milling and industrial processes coupled with efficient kiln designs resulted in considerably higher earnings per capita, leading to a healthy lifestyle for the entire tribe.

One of his most famous disciples was Baha-ud-Din Naqshband Bukhari, who used to work as an executioner in Bukhara under the rule of Qazan Khan ibn Yasaur.

Around the year 1340, Ibn Battuta made a day stop at Vabkent who later described the city as beautiful with many rivers and gardens.

After Amir Kulal's death his descendants, propagated from his four sons (Burhanudeen, Shah, Hamzah, and Omar), continued to associate with the Timurid and then Mughal dynasty kings and princes as their friends and teachers.

Although Amir Kalan is renowned for his religious scholarship he was also well versed in mathematics and astronomy, and introduced these sciences to the young prince.

At Ulugh Beg's madrasa Amir Kalan was considered one of the top ten teachers with unparalleled proficiency in ulum-i-yaainia, dinia and ulum-i-shariat.

The Shaykhan family claims ancestry from the Naqshbandi Sufi saint of Bukhara Shaykh Shams ud-Dīn Muhammad Amir Kulal.

During the early period of Islamic history the ancestors of Amir Kulal migrated from Al Madinah and settled in Shaykhan Ninawa, Iraq where successive generations lived for over five centuries.

Shaykh Sayyid Zain ud-Dīn Ibn Amir Muhammad Arifullah (d.940H/1533AD) was a writer, a poet and belonged to Naqshbandi Sufi Order.

Shaykh Zain ud-Dīn was part of Babur's entourage when he occupied Kabul in 910H/1504AD and later in 932H/1525AD in his fifth expedition to Hindustan accompanied him to India.

In his memoirs Babur writes that on entering Delhi after the victorious battle of Panipat in 932H/1526AD against Sultan Ibrahim Lodi he asked Shaykh Zain ud-Dīn to lead the Friday prayers and recite the Khutba (proclamation) in his name.

Shaykh Zain ud-Dīn was "Sadr-us-Sudur" responsible for the judicial administration and religious affairs of the Mughal Empire and also for drafting and issuing emperors decrees in accordance with the Quran and Sunnah.

Amir Mansoor Khan Ibn Khawaja Sultan Ali (d. 982H) was a senior general in the Mughal army.

During the later Mughal period, the family continued to produce eminent men of learning who distinguished themselves in various walks of life.

During the traumatic year of 1857 AD when the War of Independence started, the family played a significant role against the British.

Many died, others fled Delhi and took refuge in small towns / villages namely lncholi, Hapur, Danpur, Aounla, Sambhal, Amroha, Badarpur, Malyana and Jalali.

Shaykh Karamat Hussain along with his entire family including his eldest son Shaykh Altaf Hussain (d. 1956AD) and buried in grave yard Bibi Pak Daman, Lahore, Pakistan who was barely seven years old proceeded to Sikandarabad but feeling unsafe due to close proximity of Bulandshahr settled in his ancestor's maternal town Dibai.

The family lived in Mohalla Shaykhan (Dibai) and later also in Sikandarabad till 1947 AD when on founding of Pakistan migrated to Karachi.