He is a three term Member of the Maharashtra Legislative Assembly from the Latur city constituency.

[2][3] Son of a politician, Amit Deshmukh entered the Maharashtra political scene at a young age.

Working from the grassroots, he actively participated in the 1997 Latur Nagar Parishad elections at the age of 21, and was involved in the campaigning for Shivraj Patil in the 1999 Lok Sabha elections.

In 2009, Amit Deshmukh contested from Latur city on a Congress ticket and defeated Kayyum Khan Mohammad Khan Pathan of Bahujan Samaj Party, and Shripad Kulkarni of Shiv Sena by a margin of 89,480 votes.

[7][8] In December 2019, Deshmukh took oath as a cabinet minister in the 2019 Maharashtra Legislative Assembly.