Lobosa consists entirely of non-flagellated lobose amoebae and has been divided into two classes: Discosea, which have flattened cells, and Tubulinea, which has predominantly tube-shaped pseudopodia.

Metamonada Discoba Cryptista Rhodophyta (red algae) Picozoa Glaucophyta Viridiplantae (plants) Hemimastigophora Provora Haptista Telonemia Rhizaria Alveolata Stramenopiles One view of the great kingdoms and their stem groups.

[12][13][14][15] The Metamonada are hard to place, being sister possibly to Discoba or to Malawimonada[15] or being a paraphyletic group external to all other eukaryotes.

The three genes that are fused together in the unikonts, but not bacteria or bikonts, encode enzymes for synthesis of the pyrimidine nucleotides: carbamoyl phosphate synthase, dihydroorotase, aspartate carbamoyltransferase.

This must have involved a double fusion, a rare pair of events, supporting the shared ancestry of Opisthokonta and Amoebozoa.