The first station at Ampere was constructed in 1890 on a request made by Crocker Wheeler, a local electrical machine industry in East Orange.

The new station quickly attracted substantial ridership destined for the nearby residential and commercial areas which were growing rapidly.

This new station, costing the railroad $44,000 (1907 USD) was a new brick Renaissance Revival structure with a green terra cotta roof, a large arched doorway, and a concrete pedestrian tunnel under the tracks.

The station saw electric train service for the first time in 1930 when the Lackawanna in conjunction with Thomas Edison with overhead catenary wires.

The Crocker Wheeler plant, the original advocate for the station, closed and was bought by the Carrier Corporation to manufacture refrigerators and air conditioners.

The merged company continued to struggle, eventually declaring bankruptcy, and sought to discontinue or transfer all passenger service.

At this point, the DOT (and the newly formed New Jersey Transit) shut the inside waiting room of the deteriorating station depot.

Service was suspended at Ampere and the nearby Grove Street station on April 7, 1991, ostensibly until ridership forecasts increased substantially.

Because the station remains on the National Register of Historic Places, construction plans would need to be approved by the United States Secretary of the Interior.

A new structure would need to meet the Americans with Disabilities Act of 1990 form, with high-level platforms (51 inches (1.3 m) off the ground and 630 feet (190 m) long), new canopies, ramps and stairs.

Due to the level of usage, no more than a three-sided brick shelter, similar to those at Montclair Heights or Lake Hopatcong stations would be needed.