Amphion is an unincorporated community in Atascosa County, in the U.S. state of Texas.

It is located within the San Antonio metropolitan area.

The soil series known as "Amphion clay loam", classed as a fine, mixed, superactive, hyperthermic Pachic Paleustoll, is named after the town.

[2] Amphion is located just east of Farm to Market Road 2146, 9 mi (14 km) northwest of Pleasanton[3] and 6 mi (9.7 km) southwest of Poteet in west-central Atascosa County.

[4] Today, the community is served by the Jourdanton Independent School District.