It is a sequential hermaphrodite with a strict dominance hierarchy, features which are critical to the direction of gene flow.

[2] There has been a long-standing theory that A. leucokranosis was a naturally occurring hybrid between A. chrysopterus and A. sandaracinos,[4] with the fish being experimentally created in captivity.

This strict sized based dominance hierarchy makes the relative size of the parent species critical in shaping the outcome of hybridization[2] In this regard A. chrysopterus is one of the largest anemonefish, growing to 17 cm in length.

[2] It does not show any melanism when hosted by S. mertensii unlike some species of anemonefish, such as A. clarkii The white mark on top of the head is distinctive.

There is a substantial overlap in depth with all 3 fish found in the range of 1–10 m.[2] A. leucokranos is hosted by the following species of anemone: At Kimbe Bay A. leucokranos and its parents were primarily found in the host Stichodactyla mertensii otherwise Heteractis crispa.