Amphisbaena medemi is a species of worm lizard in the family Amphisbaenidae.

The species is endemic to Colombia.

[2] The specific name, medemi, is in honor of Federico Medem, who was a Colombian herpetologist, of Baltic German descent.

[3] In Colombia, A. medemi is found in the departments of Atlántico, Cesar, and La Guajira.

[2] The preferred habitat of A. medemi is forest at altitudes of 45–776 m (148–2,546 ft).