He worked as the headmaster of Juddhodaya Public High School in Birgunj for two years and later joined Tri-Chandra College as a lecturer in chemistry.

In 1962, he became the founding principal of Public Science College and began teaching as a professor of chemistry.

[3] Pradhan helped to establish Amrit Campus with a goal of promoting the study of science and technology in Nepal.

[3] While on a mission to the United States for academic reasons, he died in an air crash over Mont Blanc on January 24, 1966.

The campus is a governmental institution, with partial decentralization, affiliated to Tribhuvan University.