[1] Griffin grew up in Federal Way, Washington, where she attended Decatur High School and played for the club soccer team, F.C.

Griffin and teammate Michelle Akers helped lead UCF to three NCAA Tournament appearances, including a trip to the Final Four in 1987.

The New Mexico Lobos posted a 27–24–1 record under Griffin, including a 10–7–3 mark in 1995 en route to a second-place finish in the Western Athletic Conference.

[8] In 2015, Griffin was announced as the new head coach of the United States women's national deaf soccer team.

She provided analysis for ESPN2 during the 1995 and 1999 women's soccer World Cups and was the color analyst for NBC's 2000 Sydney Olympic coverage.

[5] Amy Griffin has played an important role by bringing forward concerns about the health of women soccer players, particularly goal keepers.