Amyloid purpura usually occurs above the nipple-line and is found in the webbing of the neck and in the face and eyelids.

[1] The precise cause of amyloid purpura is unknown, but several mechanisms are thought to contribute.

[2] Another contributing factor may be enhanced fibrinolysis,[2] the breakdown of clots.

[2] Amyloid purpura affects a minority of individuals with amyloidosis.

[1] For example, purpura is present early in the disease in approximately 15% of patients with primary systemic amyloidosis.