[2] The central character in the book is Brendan Tierney, a young Irish writer living in New York City with his American wife and their two children.

Conflicts arise when the mother finds that her own lifestyle, values and sense of morality are at odds with what she sees in her son and daughter-in-law's home.

Moore's biographer, Patricia Craig, says that literary ambition is the theme of An Answer from Limbo, "which - with great economy – draws on his New York experience to encapsulate the ruthlessnes of the writer hell-bent in securing a niche for himself, overriding every obstacle on the road to celebrity.

[4] According to Denis Sampson it is "a novel about marital dissatisfaction that develops into a moral fable because the dilemmas in which these characters find themselves mirror a society in spiritual and cultural crisis".

"[6] DeWitt Henry describes An Answer from Limbo as a "a minor classic" and says "All that's best in Moore is pushed to the limit here: dramatic access to manifold points of view, masterfully differentiated by style and sensibility, and in the tragic (and comic) distances between them somehow comprehensive in reference... Add also clarity and complexity of plot, strong narrative drive, the "world" of New York, and the overall sense of vital issues at stake: but most of all Moore's genius for constantly pushing decorums over the edge into "unimaginable" extremity... Moore's sense of probability has never seemed more deeply, bravely, widely knowing than our own, nor as clear-eyed, nor as fair.