An Phú is a district of An Giang province in the Mekong Delta region of Vietnam and shares the international border with Cambodia.

An Phú was a part of the Tầm Phong Long region that had links with former Funan kingdom and was given to the Nguyễn lords in 1757 by Chenla king Outey II.

In Daniel Marvin's book Expendable Elite – One Soldier's Journey into Covert Warfare, he talked about the time he worked there in the Special Forces in 1965–1966.

They set up camp in Dan Nam in An Phú town and enlisted a group of militant Hòa Hảo forces to support them.

There are about 12,000 Chams people who mostly live in 5 villages: Đa Phước, Vĩnh Trương, Nhơn Hội, Khánh Bình and Quốc Thái.

Located near Châu Đốc, An Phú district is famous for its rice and fish during the monsoonal flood season.