Ana Patricia Botín-Sanz de Sautuola O'Shea (born 4 October 1960) is a Spanish banker who has been the executive chairman of Santander Group since 2014.

Prior to this she was chief executive officer (CEO) of Santander UK, a role she held from December 2010 until her assumption of the chairmanship.

[16] Since taking charge she has brought in more international board members, embraced technology and strengthened the US and Latin America management teams.

[18] In 2020, the International Monetary Fund's Managing Director Kristalina Georgieva appointed her to an external advisory group to provide input on policy challenges.

[19] In early 2021, she was appointed by the G20 to the High Level Independent Panel (HLIP) on financing the global commons for pandemic preparedness and response, co-chaired by Ngozi Okonjo-Iweala, Tharman Shanmugaratnam and Lawrence Summers.

[30] In 1983, Botín married fellow banker Guillermo Morenés y Mariátegui, son of the 9th Marquess of Borghetto, a wealthy landowner.