She was best known, in the English speaking world, for voicing the titular character of the 2017 animated film Coco.

[1] Her early well known roles were in The Queen of the Night (1994) as Doña Victoria and as Doña Amelia in Nobody Will Speak of Us When We're Dead (1995).

At the time of her death, she was one of the last surviving stars from the Golden Age of Mexican Cinema.

[2] Murguía holds the record for the most nominations for the Ariel Award for Best Actress without a win, having been nominated a total of five times.

She also jointly holds the record, with Isela Vega, for the most Ariel Award for Best Supporting Actress wins, with three; with a further three nominations.