Her marriage to Stefan Milutin is dynastic, ie foreseen by the Deževa Agreement.
According to George Pachymeres, Ana was "the daughter of Terter, borne to him by the sister of Asen.
[1] The sister of Asen was Kira Maria- second wife of George I Terter.
According to another theory she was the daughter of George Terter and his first wife Maria,[2] making Ana a full sister of Bulgarian tsar Theodore Svetoslav.
They had: In 1299 Stefan Uroš II Milutin divorced Ana in order to marry Simonida, who was only 5 years old.